Dec 27, 2021
The first tablet designed to treat symptomatic Covid has been approved by the UK drugs board.
Molnupiravir, a pill, will be administered twice a day to individuals who have recently been diagnosed with any viral disease.
The medication, which was originally created to treat the flu, was found to reduce the risk of hospitalisation or death by roughly half in clinical trials.
The medicine, according to Sajid Javid, Secretary of State for Health, is a "gamechanger" for the frailest and most immunocompromised patients.
"Today is a historic day for our country," he said in a statement, "as the UK has become the first country in the world to approve an antiviral that may be taken at home for Covid."
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First oral treatment:
Molnupiravir was first created to treat influenza at Emory University by Drug Innovation Ventures at Emory, the university's drug development firm (DRIVE). Ridgeback Biotherapeutics, a Miami-based company, then bought it and partnered with Merck & Co. to further develop the drug.
Molnupiravir, also known as Lagevrio, is an antiviral drug that prevents the reproduction of some RNA viruses. It is used to treat COVID-19 in people who have been infected with SARS-CoV-2.
It will be administered to both vaccinated and unvaccinated patients in countrywide research at first, with additional data on its usefulness gathered before any decision to order more.
To be most effective, the medicine must be taken within five days of the onset of symptoms.
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It's unclear how the NHS will be able to distribute it so rapidly. After testing positive for Covid, some care facilities may be offered supply, while other elderly or vulnerable people may be prescribed it by their GP.
The new medication works by attacking an enzyme that the virus uses to replicate itself, causing faults in its genetic code. This should stop it from growing, keeping viral levels in the body low and reducing disease severity.
According to Merck, this technique should make the treatment as effective against new viral varieties as they emerge in the future.
Molnupiravir is a prodrug of the synthetic nucleoside derivative N4-hydroxycytidine that works against viruses by causing copying errors during viral RNA replication.
The drug's international nonproprietary name, Mjölnir, was inspired by Thor's hammer. The medicine, like a powerful blow from the god of thunder, is supposed to knock out the infection.
In October 2021, preliminary findings from a clinical trial (MOVe-OUT) suggest that molnupiravir medication may minimise the incidence of COVID-19-related hospitalisation and mortality.
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The Philippine Food and Drug Administration (FDA) granted four hospitals in the Philippines a compassionate special permit (CSP) to get molnupiravir in October 2021.
300,000 courses were purchased in Australia. Pharmac, a New Zealand pharmaceutical company, ordered 60,000 doses in October 2021.
Molnupiravir was licenced for usage in an emergency scenario by the Bangladesh Directorate General of Drug Administration (DGDA) in November 2021.
Molnupiravir was approved for medicinal use in the United Kingdom in November 2021.